SANTA CLARA — Tight end George Kittle officially will miss the 49ers’ visit Sunday to the Los Angeles Rams, and defensive end Nick Bosa is no sure thing to play either.
In downgrading Kittle on Saturday from doubtful to out, the 49ers also announced two practice-squad elevations, one of which predictably is his potential replacement, second-year tight end Brayden Willis.
The 49ers’ other practice-squad elevation was for defensive end Sam Okuayinonu. That likely is in relation to Bosa’s questionable status with a rib injury that coach Kyle Shanahan said was incurred during Thursday’s practice; Bosa was limited Friday.
The 49ers (1-1) on Friday ruled out wide receiver Deebo Samuel (calf) while listing cornerback Charvarius Ward (hamstring, knee) as questionable along with Bosa, who’s appeared in all but one game since 2021.